Unlike   synthetic   drugs,   which   are   single   active   chemical substances, phyto-pharmaceuticals contain complex mixtures of hundreds of natural components.  Among them, several   isolated   lead   substances   are well known   to   be pharmacologically    active    while    others    are    still    under scientific   investigation.   The   efficacy   of   herbal   medicinal products   results   from   complex   interactions   the   active components   with   molecular   target   structures,   such   as receptors, enzymes, and transport systems.  Herbal medicine was also the origin of conventional academic medicine. Even today,  about  70%  of  medicines  contain  active  ingredients that  were  originally  derived  from  natural  substances. Many classical   active   components,   such   as   the pain   reliever morphine, the cardiac glycoside digoxin or the anticholinergic agent atropine originate from plants.  Today, however,  such  isolated  substances  are  no  longer  considered as  phyto -pharmaceuticals  as  they  are  either  produced  by chemical synthesis or are isolated and purified to be used as single substances